• Turan Ege, Gülara Huseyin, Omer Yalcin, Melih Hulusi Us, Cavidan Arar, and Enver Duran.
• Department of Cardiovascular Surgery, Trakya University, Erdine, Turkey. turanege@ttnet.net.tr
• J. Cardiothorac. Vasc. Anesth. 2004 Apr 1; 18 (2): 166-74.

ObjectiveTo investigate the importance of pulmonary artery perfusion in cardiac surgery.DesignProspective randomized study.SettingUniversity hospital.ParticipantsPatients undergoing cardiac surgery.InterventionsPatients in whom the cross-clamp was applied only to the aorta were defined as group 1 (n = 11) and patients in whom the cross-clamp was applied to both the aorta and pulmonary artery were defined as group 2 (n = 11).Measurement And ResultsTissue samples obtained from the lower lobe of the left lung before CPB, 20 minutes after cross-clamping, and 20 minutes after declamping were examined under light and electron microscopes. Electron microscopic examination revealed changes in the blood-air barrier, epithelial cells, pneumocytes, and basal membrane were more prominent in group 2. Changes in the leukocyte, neutrophil, and lymphocyte counts of blood samples obtained from the right atrium and right superior pulmonary vein before CPB and 5, 30, 60, and 90 minutes after the removal of clamp were also investigated. The transpulmonary difference was statistically significant at 5 and 30 minutes after declamping in group 1. In group 2, transpulmonary differences continued to be significant at 5, 30, 60, and 90 minutes after declamping. There was no difference between groups in terms of PaO(2)/F(I)O(2) ratio before CPB (group 1: 342.0 +/- 80.0 mmHg, group 2: 349.0 +/- 67.0 mmHg); however, a statistically significant difference was found between the groups 2 hours after declamping (group 1: 418.0 +/- 87.0 mmHg and group 2: 290.0 +/- 110.0 mmHg; p = 0.007).ConclusionPulmonary artery perfusion was found to be important in cardiac surgery.

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