• Braz J Otorhinolaryngol · Nov 2017

    Review

    Polymorphisms in chronic rhinosinusitis with nasal polyps - a systematic review.

    • Vanessa Ramos Pires Dinarte, Anemari Ramos Dinarte Dos Santos, Araújo Luiza Ferreira de LF Universidade de São Paulo (USP), Faculdade de Medicina de Ribeirão Preto, Departamento de Genética, Ribeirão Preto, SP, Brazil., Mariah Guieiro Alves Dos Reis, Edwin Tamashiro, Valera Fabiana Cardoso Pereira FCP Universidade de São Paulo (USP), Faculdade de Medicina de Ribeirão Preto, Departamento de Oftalmologia, Otorrinolaringologia e Cirurgia, Wilson Araújo da Silva Júnior, and Wilma Terezinha Anselmo-Lima.
    • Escola de Medicina de Marília, Departamento de Otorrinolaringologia, Divisão de Otorrinolaringologia, Marília, SP, Brazil.
    • Braz J Otorhinolaryngol. 2017 Nov 1; 83 (6): 705-711.

    IntroductionChronic rhinosinusitis with nasal polyps is a multifactorial disease with a complex pathophysiology involving multiple genetic and environmental factors.ObjectiveThe purpose of this work review is to focus on the importance of genetic studies in chronic rhinosinusitis with nasal polyps besides the several barriers that exists for its understanding.MethodsA systematic review on studies of association between single nucleotide polymorphisms and chronic rhinosinusitis with nasal polyps based on a PubMed/Medline and Periódicos CAPES search of all articles published between January 2005 and January 2015 was made. The search was guided on studies containing the terms polymorphisms, rhinosinusitis, and polyps.ResultsTwo studies found an association of MMP-9 and MMP-2 polymorphisms and chronic rhinosinusitis with nasal polyps, but not in patients with recurrent nasal polyps. Other studies found an association of nasal polyps with MMP-9 polymorphisms, but not with MMP-2 ones. There is evidence of an association of LTC4S, NOS2A, PTGDR, MET, COX-2, OSF-2, and LF polymorphisms and the risk of developing nasal polyps, especially when combined with chronic allergic rhinitis and asthma.ConclusionGenetic studies on chronic rhinosinusitis with nasal polyps are promising and may offer insights into its pathophysiology, which is likely affected by multiple genetic factors.Copyright © 2017 Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial. Published by Elsevier Editora Ltda. All rights reserved.

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