• Arch Orthop Trauma Surg · Jan 1990

    Comparative Study

    Blood levels of active metabolites of vitamin D3 in fracture repair in humans. A preliminary report.

    • C Tauber, D Noff, M Noff, and C Malkin.
    • Department of Orthopaedics, Kaplan Hospital, Rehovot, Israel.
    • Arch Orthop Trauma Surg. 1990 Jan 1; 109 (5): 265-7.

    AbstractBlood levels of the active metabolites of vitamin D3, 25-hydroxycholecalciferol [25(OH)D3], 1,25-dihydroxycholecalciferol [1,25(OH)2D3] and 24,25-dihydroxycholecalciferol [24,25(OH)2D3] were determined in seven patients. Two subjects suffered from delayed union of tibial fractures; one showed a delayed union after a proximal tibial osteotomy; one patient suffered from bilateral femoral neck fractures, of which one failed to unite and the other united late; two patients had multiple fractures that united normally; and one patient exhibited staged bilateral femoral neck fractures whose occurrence was separated by a short interval and which united without undue delay. The blood levels of 25(OH)D3 were within the normal range. A relative decrease in 24,25(OH)2D3 values was noted in all patients, whereas in three subjects the decrease was absolute, to non-detectable levels. A decrease in 1,25(OH)2D3 levels was noted in only two patients. We postulate that these changes reflect the consumption of these metabolites during healing at the fracture site.

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