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Arch Orthop Trauma Surg · Jan 1991
Comparative StudyQuantitative comparison of the histological effects of particulate polymethylmethacrylate versus polyethylene in the rabbit tibia.
- S B Goodman, V L Fornasier, and J Kei.
- Stanford University Medical Center, Division of Orthopaedic Surgery, Ca 94305.
- Arch Orthop Trauma Surg. 1991 Jan 1; 110 (3): 123-6.
AbstractFourteen mature female New Zealand White rabbits underwent implantation of Simplex polymethylmethacrylate (PMMA) powder or particulate (average 67 microns) ultrahigh-molecular-weight polyethylene (UHMWPE) through a drill hole in the proximal right tibia. The left tibia functioned as a prepared but nonimplanted control. Animals were killed after 16 weeks. Histological examination of the bone-implant interface in the particulate PMMA group disclosed a florid foreign-body reaction with the presence of giant cells and histiocytes. The particulate UHMWPE group demonstrated positively birefringent UHMWPE fragments, rimmed by foreign-body giant cells and histiocytes, embedded in a loose connective tissue stroma. UHMWPE interfaces were thicker and contained more histiocytes and fibrocytes; PMMA interfaces contained more marrow cells and lymphocytes. This study underscores the importance of biomaterial debris in the process of aseptic loosening of cemented joint arthroplasties.
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