• Arch Orthop Trauma Surg · Jan 1992

    Case Reports

    Fibrous dysplasia with locally aggressive malignant change.

    • P D Latham, N A Athanasou, and C G Woods.
    • Nuffield Department of Orthopaedic Surgery, Nuffield Orthopaedic Centre, Headington, Oxford, UK.
    • Arch Orthop Trauma Surg. 1992 Jan 1; 111 (3): 183-6.

    AbstractThis is a case report of a tumour which showed all the histological features of fibrous dysplasia without any features of high-grade malignancy, yet had become locally aggressive, causing cortical erosion and extension into soft tissue. Fibrous dysplasia is a well-recognised entity that encompasses monostotic lesions, polyostotic involvement and Albright's syndrome [6, 8]. Lesions in bone usually spare the epiphysis before puberty, but often involve the epiphyseal area after maturity and can progress during adult life [3]. Unless cystic [6, 10] or malignant change [7, 10, 11] occurs, fibrous dysplasia usually remains contained within bone.

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