• Arch Orthop Trauma Surg · Jan 1992

    Intra-articular injections and articular cartilage metabolism. An experimental study in rabbits.

    • J Neidel, J Schmidt, and M H Hackenbroch.
    • Klinik und Poliklinik für Orthopädie, Universität zu Köln, FRG.
    • Arch Orthop Trauma Surg. 1992 Jan 1; 111 (4): 237-41.

    AbstractWe studied the effects of repeated intra-articular injections of sterile 140 mM NaCl solution on articular cartilage in adult rabbits. After 20 injections into the knee joints over a period of 4 weeks, chondrocyte glucosaminoglycan synthesis was evenly reduced in all cartilage layers, accompanied by a significant proteoglycan depletion of the matrix which was most marked in the superficial half of the cartilage. These and other changes only partially reversed during a further 4-week period after the injections had been stopped. Our data underline the need for a clear-cut indication for intra-articular injections. The microtrauma caused by injection, in conjunction with the introduction of a carrier solution into the joint, may, at least when repeated at short intervals, lead to measurable damage to the articular cartilage.

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