• Arch Orthop Trauma Surg · Jan 2010

    Clinical application of BMP 7 in long bone non-unions.

    • Arash Moghaddam, Charlotte Elleser, Bahram Biglari, Andreas Wentzensen, and Gerald Zimmermann.
    • BG Trauma Center Ludwigshafen, Unfallchirurgische Klinik, University of Heidelberg, Ludwig, Guttmann, Str. 13, 67071, Ludwigshafen, Germany. moghaddam@bgu-ludwigshafen.de
    • Arch Orthop Trauma Surg. 2010 Jan 1; 130 (1): 71-6.

    BackgroundNon-unions of long bone fractures are a therapeutic and economic problem of increasing frequency. Aside from conservative treatment options such as ultrasound, impulse waves, and casts, the basic surgical options are autogenous cancellous bone grafting, rod dynamization, reamed nailing, plate fixation, and bone transport techniques. If these methods fail to work, there is a need for alternative treatment options.MethodsSince May 2001, treatment with recombinant human bone morphogenic protein 7 (BMP 7 or osteogenic protein 1) in combination with a type-one collagen carrier has been the subject of increasing interest. BMP 7 induces the formation of new bone by stem cell differentiation, thereby initiating the reaction cascade of osteogenesis. Non-unions over 9 months and unsuccessful bone grafting constitute the indication for this treatment.ResultsWe report our experience with 54 patients who had atrophic non-union of long bone fractures. Between May 2002 and May 2006, 57 units of BMP 7 were used. The localization of the non-unions included 21 in the femur, 26 in the tibia, 3 in the humerus and 7 in the forearm. In 36 cases, BMP 7 was used in combination with osteosynthesis revision and bone grafting; in 9 additional patients, BMP 7 was used with bone grafting alone. In 12 patients, BMP 7 was applied as a single procedure without any bone grafting or any change in osteosynthesis.ConclusionsThere were no perioperative or postoperative complications. Follow-up was obtained for a minimum of 6 months. 47 of the 57 (82%) implantations were successful, with bony healing confirmed by clinical and radiological evaluation. In summary, our results support BMP 7 as an additional innovative therapy for long bone non-unions.

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