• Marcelo Park, Pedro Vitale Mendes, Fernando Godinho Zampieri, Azevedo Luciano Cesar Pontes LC Faculdade de Medicina, Hospital das Clínicas, Universidade de São Paulo, São Paulo, SP, Brasil., Costa Eduardo Leite Vieira EL Unidade de Terapia Intensiva, Hospital Sírio Libanês, São Paulo, SP, Brasil., Fernando Antoniali, Gustavo Calado de Aguiar Ribeiro, Luiz Fernando Caneo, Luiz Monteiro da Cruz Neto, Carvalho Carlos Roberto Ribeiro CR Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil., Evelinda Marramon Trindade, ERICC research group, and ECMO group Hospital Sírio Libanês and Hospital das Clínicas de São Paulo.
• Faculdade de Medicina, Hospital das Clínicas, Universidade de São Paulo, São Paulo, SP, Brasil.
• Rev Bras Ter Intensiva. 2014 Jul 1; 26 (3): 253-62.

ObjectiveTo analyze the cost-utility of using extracorporeal oxygenation for patients with severe acute respiratory distress syndrome in Brazil.MethodsA decision tree was constructed using databases from previously published studies. Costs were taken from the average price paid by the Brazilian Unified Health System (Sistema Único de Saúde; SUS) over three months in 2011. Using the data of 10,000,000 simulated patients with predetermined outcomes and costs, an analysis was performed of the ratio between cost increase and years of life gained, adjusted for quality (cost-utility), with survival rates of 40 and 60% for patients using extracorporeal membrane oxygenation.ResultsThe decision tree resulted in 16 outcomes with different life support techniques. With survival rates of 40 and 60%, respectively, the increased costs were R$=-301.00/-14.00, with a cost of R$=-30,913.00/-1,752.00 paid per six-month quality-adjusted life-year gained and R$=-2,386.00/-90.00 per quality-adjusted life-year gained until the end of life, when all patients with severe ARDS were analyzed. Analyzing only patients with severe hypoxemia (i.e., a ratio of partial oxygen pressure in the blood to the fraction of inspired oxygen <100 mmHg), the increased cost was R$=-5,714.00/272.00, with a cost per six-month quality-adjusted life-year gained of R$=-9,521.00/293.00 and a cost of R$=-280.00/7.00 per quality-adjusted life-year gained.ConclusionThe cost-utility ratio associated with the use of extracorporeal membrane oxygenation in Brazil is potentially acceptable according to this hypothetical study.

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