• Curr Opin Crit Care · Dec 2019

    Review

    Sudden unresponsive patient with normal vital signs: what is going on?

    • Lisa Smit, Kelly A Foks, Jeannette Hofmeijer, and Mathieu van der Jagt.
    • Department of Intensive Care Adults.
    • Curr Opin Crit Care. 2019 Dec 1; 25 (6): 653-660.

    Purpose Of ReviewTo summarize the differential diagnosis and diagnostic approach of sudden unresponsiveness with normal vital signs in various settings, including the ICU.Recent FindingsSudden unresponsiveness may be either transient or persistent, and may result from primary brain diseases or nonstructural systemic conditions. Life-threatening causes should always be discriminated from those more benign. Regional epidemiology, for example regarding intoxications, and evolving therapeutic management, for example for ischemic stroke, should always be taken into account for optimal opportunity for rapid diagnosis and best management.SummarySudden unresponsiveness with normal vital signs should trigger immediate and focused diagnostic evaluation to find or exclude those conditions requiring urgent, and possibly life-saving, management.

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