1H magnetic resonance spectroscopy in multiple sclerosis and

Neuroimaging Clin. N. Am. · Aug 2013

Review

1H magnetic resonance spectroscopy in multiple sclerosis and related disorders.

Proton magnetic resonance spectroscopy ((1)H-MRS) is an unconventional technique that allows noninvasive characterization of metabolic abnormalities in the central nervous system. (1)H-MRS provides important insights into the chemical-pathologic changes that occur in patients with multiple sclerosis (MS). In this review article we present the main brain and spinal cord (1)H-MRS features in MS, their diagnostic value in differentiating pseudotumoral demyelinating lesions from primary brain tumors, and their relationship with clinical variables. Last, some data related to the use of (1)H-MRS in therapeutic trials is presented.

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- Alex Rovira and Juli Alonso.
- Department of Radiology, Magnetic Resonance Unit (IDI), Vall d'Hebron Research Institute, Vall d'Hebron University Hospital, Barcelona 08035, Spain. alex.rovira@idi-cat.org
- Neuroimaging Clin. N. Am.. 2013 Aug 1;23(3):459-74.
AbstractProton magnetic resonance spectroscopy ((1)H-MRS) is an unconventional technique that allows noninvasive characterization of metabolic abnormalities in the central nervous system. (1)H-MRS provides important insights into the chemical-pathologic changes that occur in patients with multiple sclerosis (MS). In this review article we present the main brain and spinal cord (1)H-MRS features in MS, their diagnostic value in differentiating pseudotumoral demyelinating lesions from primary brain tumors, and their relationship with clinical variables. Last, some data related to the use of (1)H-MRS in therapeutic trials is presented.Copyright © 2013 Elsevier Inc. All rights reserved.

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1H magnetic resonance spectroscopy in multiple sclerosis and related disorders.

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