• Arch Orthop Trauma Surg · Jan 2001

    Effect of preoperative chemotherapy on the outcome of surgical treatment of vertebral tuberculosis: retrospective analysis of 434 cases.

    • E Alici, O Akçali, H Tatari, and I Günal.
    • Department of Orthopedics, Dokuz Eylül University Hospital, Izmir, Turkey.
    • Arch Orthop Trauma Surg. 2001 Jan 1; 121 (1-2): 65-6.

    AbstractA retrospective analysis of 434 patients with vertebral tuberculosis who were treated surgically was performed with special reference to the preoperative duration of chemotherapy. Of these, 376 underwent 4 weeks of a chemotherapy regimen with isoniazid, rifampin and ethamburol, and in 2 re-activation of the disease was observed. The remaining 58 underwent operation for neurological impairment with 6-18 h of the same chemotherapy regimen, and in no case did re-activation occur. These results suggest a shorter duration of chemotherapy may be utilised in all patients undergoing surgical treatment for vertebral tuberculosis, providing a thorough debridement is performed, leaving no necrotic or infected tissue behind.

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