• Arch Orthop Trauma Surg · May 2001

    Causes of the clinical tissue response to polyglycolide and polylactide implants with an emphasis on the knee.

    • P Tuompo, E K Paritio, H Pätiälä, K Jukkala-Partio, E Hirvensalo, and P Rokkanen.
    • Helsinki University Central Hospital, Töölö Hospital, Department of Orthopaedics and Traumatology, Finland. pertti.tuompo@pp.inet.fi
    • Arch Orthop Trauma Surg. 2001 May 1; 121 (5): 261-4.

    AbstractThe causes of a clinical tissue response to self-reinforced polyglycolide (SR-PGA) and self-reinforced polylactide (SR-PLLA) implants were studied in the first 2500 polymeric fixations. The incidence was 8.0% in fixations with implants made of SR-PGA (n = 1879) and 0% in SR-PLLA fixations (n = 621). A small number of fixations per site seemed to increase the incidence of a tissue response. In diagnoses involving over 50 fixations, except for ankle fractures, the incidence was 4.2%. The site of fixation influenced the incidence; the lowest incidence was seen for radial head fracture fixation (1.1%). The aromatic dye which has not been used since 1988 in the SR-PGA implant increased the response. A large total implant volume and a large number of implants increased the incidence of a tissue response. In the knee (n = 131), the incidence of a clinical tissue response was 4.3%, with four fluid accumulations and one synovitis of the knee after fixation with SR-PGA implants.

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