• Paediatric anaesthesia · Nov 2002

    Repeated administration of ketamine may lead to neuronal degeneration in the developing rat brain.

    • Hideaki Hayashi, Pieter Dikkes, and Soriano Sulpicio G SG.
    • Department of Anesthesia, Kansai Rosai Hospital, Japan.
    • Paediatr Anaesth. 2002 Nov 1; 12 (9): 770-4.

    BackgroundThis study was conducted to investigate, in vivo, the dose and duration effects of ketamine administration on neuronal degeneration in the developing rat brain.MethodsSeven-day-old (P7) Sprague-Dawley rats were treated with intraperitoneal injections of ketamine, a noncompetitive N-methyl-D-aspartate receptor antagonist. Degenerating neurones were identified by the cupric-silver stain from 10 brain regions using the stereological disector method.ResultsA single dose of ketamine (25, 50 and 75 mg.kg-1) did not increase neuronal degeneration compared with the saline-treated control. However, repeated doses of ketamine (25 mg.kg-1) at 90-min intervals over 9 h increased degenerating neurones in seven out of 10 brain regions.ConclusionsThese findings suggest that the duration of ketamine exposure correlates with increased neuronal degeneration in the developing rat brain.

      Pubmed     Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…