• Neuroimaging Clin. N. Am. · Feb 2015

    Review

    Molecular imaging in genetics.

    • José Leite, Roberta Hespanhol, and Carlos Alberto Buchpiguel.
    • PET/CT, Clínica de Diagnóstico Por Imagem (CDPI), Rio de Janeiro, Rio de Janeiro, Brazil. Electronic address: leite_jose@yahoo.com.
    • Neuroimaging Clin. N. Am.. 2015 Feb 1;25(1):17-29.

    AbstractNeuroimaging is a potentially valuable tool to link individual differences in the human genome to structure and functional variations, narrowing the gaps in the casual chain from a given genetic variation to a brain disorder. Because genes are not usually expressed at the level of mental behavior, but are mediated by their molecular and cellular effects, molecular imaging could play a key role. This article reviews the literature using molecular imaging as an intermediate phenotype and/or biomarker for illness related to certain genetic alterations, focusing on the most common neurodegenerative disorders, Alzheimer's disease (AD) and Parkinson disease.Copyright © 2015 Elsevier Inc. All rights reserved.

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