• Neuroimaging Clin. N. Am. · Feb 2015

    Review

    Imaging phenotypes in multiple sclerosis.

    • Stefan Dirk Roosendaal and Frederik Barkhof.
    • Department of Radiology & Nuclear Medicine, Neuroscience Campus Amsterdam, VU University Medical Center, PO Box 7057, Amsterdam, 1007 MB, The Netherlands. Electronic address: stefanmed@yahoo.com.
    • Neuroimaging Clin. N. Am.. 2015 Feb 1;25(1):83-96.

    AbstractMultiple sclerosis (MS) is a common disease of the central nervous system, with various clinical symptoms and a heterogeneous disease course. MRI can depict focal and diffuse manifestations of the disease, and accurately measure progression over time. The precise pathogenesis of MS is unknown. Nevertheless, genetic influences have been found for susceptibility to MS in linkage and association studies. More recent genome-wide association studies have revealed other genes to be related to disease susceptibility and severity, explaining part of the variability in symptoms, radiological manifestations and disease course. Studies relating genetics and imaging in MS are discussed in this paper.Copyright © 2015 Elsevier Inc. All rights reserved.

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