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Neuroimaging Clin. N. Am. · Feb 2015
ReviewNeuroimaging and genetic influence in treating brain neoplasms.
- L Celso Hygino da Cruz and Margareth Kimura.
- MRI Department of Clínica de Diagnostico por Imagem (CDPI) and IRM Ressonância Magnética, Av. das Américas, 4666 Sl 325, Centro Médico Barrashopping, Rio de Janeiro, RJ, Brazil. Electronic address: celsohygino@hotmail.com.
- Neuroimaging Clin. N. Am.. 2015 Feb 1;25(1):121-40.
AbstractThe current treatment of glioblastoma patients based on surgery, radiation, and chemotherapy has achieved modest improvement in progression-free survival. In this direction, personalized treatment is the next achievement for better patient management and increased overall survival. Genetic characterization of high-grade gliomas by MR imaging is the goal in neuroimaging. The main genetic alterations described in these neoplasms, implications in patient treatment, and prognosis are reviewed. MR imaging features and novel techniques are correlated with the main genetic aspects of such tumors. Posttreatment phenomena, such as pseudoprogression and pseudoresponse, are analyzed in association with the genetic expression of these tumors.Copyright © 2015 Elsevier Inc. All rights reserved.
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