• Best Pract Res Clin Anaesthesiol · Jun 2019

    Review

    Perioperative goal-directed therapy - What is the evidence?

    • Thomas Kaufmann, Bernd Saugel, and Scheeren Thomas W L TWL Department of Anesthesiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, P.O. Box 30.001, 9700 RB, Groningen, the.
    • Department of Anesthesiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, P.O. Box 30.001, 9700 RB, Groningen, the Netherlands. Electronic address: t.kaufmann@umcg.nl.
    • Best Pract Res Clin Anaesthesiol. 2019 Jun 1; 33 (2): 179-187.

    AbstractPerioperative goal-directed therapy aims at optimizing global hemodynamics during the perioperative period by titrating fluids, vasopressors, and/or inotropes to predefined hemodynamic goals. There is evidence on the benefit of perioperative goal-directed therapy, but its adoption into clinical practice is slow and incomprehensive. Current evidence indicates that treating patients according to perioperative goal-directed therapy protocols reduces morbidity and mortality, particularly in patients having high-risk surgery. Perioperative goal-directed therapy protocols need to be started early, should include vasoactive agents in addition to fluids, and should target blood flow related variables. Future promising developments in the field of perioperative goal-directed therapy include personalized hemodynamic management and closed-loop system management.Copyright © 2019 Elsevier Ltd. All rights reserved.

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