• Zhenyin Liu, Yong Xu, Jie An, Junjing Wang, Xiangyuan Yin, Ruiwang Huang, Xiaofei Lv, Lina Chen, Wensheng Wang, and Shijun Qiu.
• Department of Medical Imaging Center, Nanfang Hospital, Southern Medical University, China.
• J Neuroimaging. 2015 May 1;25(3):460-4.

Background And PurposeThe aim of this study is to explore the possible changed cerebral white matter regions in patients with temporal lobe epilepsy (TLE) using diffusion tensor imaging (DTI) and tract-based spatial statistics (TBSS).MethodsTwenty TLE patients and 22 age- and gender-matched normal controls were included in this study. Voxel-wise analyses of multiple diffusion metrics, including fractional anisotropy (FA) and mean diffusivity (MD) were performed with TBSS.ResultsTLE patients exhibited significantly reduced FA in widespread white matter regions including bilateral limbic circuit, corpus callosum, thalamus, internal/external capsule, temporooccipital connections, frontotemporal connections; increase of MD was exhibited significantly almost in the left hemisphere. A significant decrease in global FA integrity was shown in epilepsy subjects compared to healthy controls. Furthermore, it exhibited a significant positive correlation between the disease duration and MD of whole brain.ConclusionsTLE is associated with widespread abnormalities in cerebral white matter tracts and these changes may have important clinical consequences.Copyright © 2014 by the American Society of Neuroimaging.

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