• J Neuroimaging · Nov 2015

    Case Reports

    Reversible Splenial Lesion Syndrome (RESLES) Following Glufosinate Ammonium Poisoning.

    • Tae Oh Jeong, Jae Chol Yoon, Jae Baek Lee, Young Ho Jin, and Seung Bae Hwang.
    • Research Institute of Clinical Medicine of Chonbuk National University, Emergency Medicine, Jeonju-si, Republic of Korea.
    • J Neuroimaging. 2015 Nov 1; 25 (6): 1050-2.

    AbstractIsolated and reversible lesion restricted to the splenium of the corpus callosum, known as reversible splenial lesion syndrome, have been reported in patients with infection, high-altitude cerebral edema, seizures, antiepileptic drug withdrawal, or metabolic disturbances. Here, we report a 39-year-old female patient with glufosinate ammonium (GLA) poisoning who presented with confusion and amnesia. Diffusion-weighted magnetic resonance imaging of the brain revealed cytotoxic edema of the splenium of the corpus callosum. The lesion was not present on follow-up MR imaging performed 9 months later. We postulate that a GLA-induced excitotoxic mechanism was the cause of this reversible splenial lesion.Copyright © 2015 by the American Society of Neuroimaging.

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