• Acta Obstet Gynecol Scand · Sep 2012

    Use of analgesic drugs and risk of ovarian cancer: results from a Danish case-control study.

    • Henriette B Ammundsen, Mette T Faber, Allan Jensen, Estrid Høgdall, Jan Blaakaer, Claus Høgdall, and Susanne K Kjaer.
    • Danish Cancer Society Research Center, Copenhagen, Denmark.
    • Acta Obstet Gynecol Scand. 2012 Sep 1; 91 (9): 1094-102.

    ObjectiveThe role of analgesic drug use in development of ovarian cancer is not fully understood. We examined the association between analgesic use and risk of ovarian cancer. In addition, we examined whether the association differed according to histological types.DesignPopulation-based case-control study.SettingDenmark in the period 1995-1999.PopulationWe included 756 women with epithelial ovarian cancer and 1564 randomly selected control women aged 35-79 years.MethodsInformation on analgesic drug use was collected from personal interviews. Analgesic drugs were divided into the following categories: any analgesics; aspirin; non-aspirin non-steroidal anti-inflammatory drugs; paracetamol; and other analgesic drugs. The association between analgesic drug use and ovarian cancer risk was analysed using multiple logistic regression models. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated.Main Outcome MeasuresEpithelial ovarian cancer.ResultsWomen with a regular use of any analgesics (OR = 0.79; 95% CI 0.62 - 1.01) or aspirin (OR = 0.68; 95% CI 0.46 - 1.02) had a decreased risk of ovarian cancer, although not statistically significant. Regular use of non-aspirin non-steroidal anti-inflammatory drugs, paracetamol or other analgesics did not decrease ovarian cancer risk. Use of any analgesics (OR = 0.72; 95% CI 0.53-0.98) or aspirin (OR = 0.60; 95% CI 0.36-1.00) resulted in a statistically significant decreased risk of serous ovarian cancer but not mucinous or other ovarian tumors.ConclusionIn accordance with most previous studies, our results indicate a possible inverse association between analgesic use, particularly aspirin, and ovarian cancer risk.© 2012 The Authors  Acta Obstetricia et Gynecologica Scandinavica© 2012 Nordic Federation of Societies of Obstetrics and Gynecology.

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