• Juan Antonio Hernández-Tamames, Virginia Mato Abad, Roberto García-Álvarez, Javier González-Zabaleta, Javier Pereira Loureiro, and Juan Álvarez-Linera.
• Laboratorio de Análisis de Imagen Médica y Biometría (LAIMBIO), Universidad Rey Juan Carlos, Madrid, Spain.
• J Neuroimaging. 2016 Jan 1; 26 (1): 58-61.

PurposeThis work studies the relationship between in-vitro Proton Magnetic Resonance Spectroscopy metabolite quantification and water T2 decay.Materials And MethodsAn in-vitro correspondence is established between the iron accumulation and the shortening of water T2 relaxation times using seven spherical phantoms, 6 of them were doped with an increasing concentration of iron metal nanoparticles solution. This is later proposed as a source of error during the LCModel metabolite quantification of either absolute concentrations or ratios.ResultsThe Pearson's correlation coefficient between water T2 values against absolute metabolite concentrations was on average [r] = 0.97 and on average [r] = 0.85 for metabolite ratios.ConclusionThese results suggest that the shortening of T2 values should be taken into account when performing metabolite quantification. Also, the need of demonstrated similar results in in-vivo studies, since the presence of iron deposits or other factors affecting the water T2 decay measurements could explain part of the inter-subject variability in the metabolite concentration and ratio quantification.Copyright © 2015 by the American Society of Neuroimaging.

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