• Yuan-Bo Zheng, Guo-Mo Ruan, Jia-Xing Fu, Zhong-Liang Su, Peng Cheng, and Jian-Zuo Lu.
• Department of Orthopedics, The People's Hospital of Wenzhou City, 57 Canghou Lane, Wenzhou 325000, China.
• Clin. Chim. Acta. 2016 Apr 1; 455: 149-53.

BackgroundOxidative stress may be involved in occurrence of postoperative delirium (POD) and cognitive dysfunction (POCD). 8-iso-Prostaglandin F2α (8-iso-PGF2α), an isoprostane derived from arachidonic acid via lipid peroxidation, is considered a gold standard for measuring oxidative stress. The present study aimed to investigate the ability of postoperative plasma 8-iso-PGF2α levels to predict POD and POCD in elderly patients undergoing hip fracture surgery.MethodsPostoperative plasma 8-iso-PGF2α levels of 182 patients were measured by an enzyme-linked immunosorbent assay. We assessed the relationships between plasma 8-iso-PGF2α levels and the risk of POD and POCD using a multivariate analysis.ResultsPlasma 8-iso-PGF2α levels and age were identified as the independent predictors for POD and POCD. Based on areas under receiver operating characteristic curve, the predictive values of 8-iso-PGF2α were obviously higher than those of age for POD and POCD. In a combined logistic-regression model, 8-iso-PGF2α significantly enhanced the areas under curve of age for prediction of POD and POCD.ConclusionsPostoperative plasma 8-iso-PGF2α levels may have the potential to predict POD and POCD in elder patients undergoing hip fracture surgery.Copyright © 2016 Elsevier B.V. All rights reserved.

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