• Clin J Pain · Mar 1990

    Randomized Controlled Trial Clinical Trial

    Effectiveness of alprazolam in the treatment of chronic pain: results of a preliminary study.

    • L Westbrook, R S Cicala, and H Wright.
    • Department of Anesthesiology, University of Tennessee, Memphis.
    • Clin J Pain. 1990 Mar 1; 6 (1): 32-6.

    AbstractOne hundred chronic pain patients were begun on alprazolam, 1.5 mg/day. No other medication changes or therapeutic interventions were made. Sixteen patients were lost to follow-up and 1 oncology patient died. Of the 83 patients who were evaluated at 12 weeks, 61 (73.5%) showed improvement, and only 5 had discontinued the medication because of side effects. The average score of all patients had decreased from 3.6 to 2.2 on a verbal analog scale that rated pain severity from 0 to 5. There was no difference in response among the various diagnostic groups represented in the study population.

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