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Case Reports
Headache in acromegaly: dramatic improvement with the somatostatin analogue SMS 201-995.
- N R Musolino, R Marino Júnior, and M D Bronstein.
- Division of Functional Neurosurgery, Hospital das Clínicas, University of Sao Paulo Medical School, Brazil.
- Clin J Pain. 1990 Sep 1; 6 (3): 243-5.
AbstractTwo acromegalic patients with severe headache, persisting after pituitary adenomectomy followed by radiotherapy in one, were treated with the somatostatin analogue SMS 201-995. Both had been resistant to conventional headache therapy and experienced dramatic and rapid relief after the first injection of the analogue. This result persisted with long-term treatment of the drug. Although the mechanism of action of SMS 201-995 in pain remains unclear, the rapid and efficacious analgesic effect of this compound may be one more indication for its use in pituitary tumors associated with cephalalgias.
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