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- Y Shir, S S Shapira, Z Shenkman, B Kaufman, and F Magora.
- Department of Anesthesiology, Hadassah University Hospital, Jerusalem, Israel.
- Clin J Pain. 1991 Dec 1; 7 (4): 339-41.
AbstractSeventy cancer patients suffering from visceral or somatic pain received continuous epidural methadone (EM) analgesia. Initially, 4 mg of 0.1% methadone was given three times daily. If this dose proved ineffective, it was gradually increased to 8 mg four times daily. With this regimen good pain control was obtained in 56 patients (80%). Patients continued the EM therapy for periods up to 140 days, with an average duration of 27 days. Morphine was substituted for methadone in 14 patients (20%). Four of these patients responded well and continued treatment for an average of 18 days. No serious side effects have been observed with EM. With a proper selection of patients and following strict therapy guidelines, epidural methadone is efficacious in treating cancer pain.
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