-
Schweiz. Rundsch. Med. Prax. · Sep 1993
[Psychopharmacological models of drug dependence. Key role of the dopaminergic mesolimbic system].
- A Wallnöfer.
- Centre for Human Drug Research, University Hospital Leiden, The Netherlands.
- Schweiz. Rundsch. Med. Prax. 1993 Sep 14; 82 (37): 999-1003.
AbstractThe potential of a compound to induce drug dependency may be described as an interaction of its positive reinforcing and its discriminative as well as its aversive properties. Environmental factors and conditioning play thereby important, modulating roles. Drugs of abuse act via central mechanisms which mediate basal sensations such as reward and satisfaction. Neurochemical and neuroanatomical investigations suggest a key role of the dopaminergic mesolimbic system in these processes. Addictive drugs from several pharmacological classes have in common to stimulate the dopaminergic mesolimbic system, albeit by different mechanisms. However, other non dopaminergic neurotransmitter systems, e.g. the GABAergic, the opioid or the serotonergic system, are also involved in drug-seeking behaviour.
Notes
Knowledge, pearl, summary or comment to share?You can also include formatting, links, images and footnotes in your notes
- Simple formatting can be added to notes, such as
*italics*,_underline_or**bold**. - Superscript can be denoted by
<sup>text</sup>and subscript<sub>text</sub>. - Numbered or bulleted lists can be created using either numbered lines
1. 2. 3., hyphens-or asterisks*. - Links can be included with:
[my link to pubmed](http://pubmed.com) - Images can be included with:
 - For footnotes use
[^1](This is a footnote.)inline. - Or use an inline reference
[^1]to refer to a longer footnote elseweher in the document[^1]: This is a long footnote..