• Dario Kohlbrenner, Christian Benden, and Thomas Radtke.
• Division of Pulmonology and Physiotherapy Occupational Therapy, University Hospital Zurich, Switzerland.
• Respir Care. 2020 Apr 1; 65 (4): 437-443.

BackgroundThe 6-min walk test (6MWT) is a well-established functional exercise capacity test in lung transplant candidates. This study aimed to investigate the construct validity of the 1-min sit-to-stand test (1-min STS) as a marker of exercise capacity and knee extensor strength in lung transplantation candidates.MethodsWe retrospectively analyzed data from consecutive subjects referred for lung transplantation evaluation to our institution between 2015 and 2018.Results38 subjects were included. We found strong correlations between the normalized 1-min STS and 6MWT (r = 0.79, P < .001) and moderate correlations between 1-min STS and knee extensor strength (r = 0.53, P = .001) and between 6MWT and knee extensor strength (r = 0.44, P = .008). The 1-min STS elicited greater dyspnea (P = .008) and lower oxygen desaturation compared to the 6MWT (P < .001).ConclusionsThe 1-min STS is a valid functional exercise capacity test in lung transplantation candidates. Due to its ease of application, clinical practitioners may consider using the 1-min STS in situations when the 6MWT cannot be performed. Our pilot study may stimulate future research, including a head-to-head comparison between the 6MWT and 1-min STS in a large patient cohort including post-lung transplantation-monitoring.Copyright © 2020 by Daedalus Enterprises.

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