• N Timezguid, V Das, A Hamdi, M Ciroldi, D Sfoggia-Besserat, R Chelha, E Obadia, and J-L Pallot.
• Service de Réanimation Polyvalente Adulte, Centre Hospitalier Intercommunal André Grégoire, Montreuil, France.
• Int J Obstet Anesth. 2012 Jan 1;21(1):51-5.

BackgroundPrevious studies on severe maternal sepsis during pregnancy or the postpartum period are rare and have focused on septic abortion. Voluntary abortion was legalized in France in 1975. This study was conducted to reassess the characteristics of maternal sepsis that have been managed in a French intensive care unit.MethodsA retrospective study of 66 women admitted to an intensive care unit for sepsis from 1977-2008 was performed. Data on sources of infection, microbial agents and maternal and fetal outcomes were collected. Data from 1977-1992 and 1993-2008 were compared.ResultsOver time, the rate of intensive care admission for maternal sepsis did not change (0.75 episodes per 1000 deliveries in 1977-1992 versus 0.72/1000 in 1993-2008, P=1.0). The percentage of septic abortions decreased from 14% to 0%, whereas that of antepartum infections increased from 50% to 79% (P<0.01). The percentage of non-bacterial infections increased from 0% to 19% (P=0.04), and the percentage of pelvic infections had a tendency to decrease from 54% to 27% (P=0.06). Pelvic infections were due to enterobacteriaceae (50%), gram-positive cocci (45%), and/or anaerobes (23%). Maternal and fetal mortality rates were 6% and 33%, respectively.ConclusionsOver time, our intensive care unit has seen fewer cases of septic abortion. However, maternal sepsis remained a cause of intensive care admission and both maternal and fetal death. The percentages of antepartum and non-bacterial infections have increased over time. A prospective multicentre study is required to confirm these results and to investigate questions such as the effect of maternal sepsis on long-term fetal outcome.Copyright © 2011 Elsevier Ltd. All rights reserved.

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