Osteopetrosis is a disease in which a disturbance in the resorption of bone formed by endochondral ossification takes place. The cause of the osteoclast insufficiency is unknown. ⋯ We also found the macrophage marker CD 68 in these osteoclast cells, whereas other mononuclear phagocytic cells were not present in the vicinity of osteoclasts. The inhibition of osteoclast cells by phagocytes is unlikely.
O Kilian, J Kriegsmann, T Hansen, U Horas, J P Stahl, and R Schnettler.
Klinik und Poliklinik für Unfallchirurgie, Justus-Liebig-Universität, R.-Buchheim-Strasse 7, 35382 Giessen. olaf.kilian@chiru.med.uni-giessen.de
Unfallchirurg. 2001 Oct 1; 104 (10): 1014-9.
AbstractOsteopetrosis is a disease in which a disturbance in the resorption of bone formed by endochondral ossification takes place. The cause of the osteoclast insufficiency is unknown. In the literature, the etiology of the disease is discussed in relation to the complete absence of cathepsin K synthesis, a cysteine protease. In our case report, we demonstrated cathepsin K expression in the osteoclast cells of the benign form of osteopetrosis. We also found the macrophage marker CD 68 in these osteoclast cells, whereas other mononuclear phagocytic cells were not present in the vicinity of osteoclasts. The inhibition of osteoclast cells by phagocytes is unlikely.