• Gemma Taylor, Amy Taylor, Marcus R Munafò, Ann McNeill, and Paul Aveyard.
• Primary Care Clinical Sciences, School of Health & Population Sciences, University of Birmingham, Birmingham, UK UK Centre for Tobacco and Alcohol Studies, UK.
• BMJ Open. 2015 May 15; 5 (5): e007812.

ObjectivesThe association between smoking reduction and mental health is of particular interest given that many smokers report that smoking offers mental health benefits. We aimed to assess the association between smoking reduction and change in mental health using two different analytical approaches to determine if there was any evidence of an association. There were no prior hypotheses.DesignA secondary analysis of prospective individual level patient data from 5 merged placebo-controlled randomised trials of nicotine replacement therapy for smoking reduction.ParticipantsAll participants were adult smokers, selected because they wanted to reduce but not stop smoking, and had smoked for at least 3 years. Participants were excluded if they were pregnant, breastfeeding, under psychiatric care, deemed to be unfit by a general practitioner, or part of a cessation programme. 2066 participants were enrolled in the trials, 177 participants were biologically validated as prolonged reducers, and 509 as continuing smokers at both 6-week and 18-week follow-ups.Primary OutcomeChange in mental health from baseline to an 18-week follow-up was measured using the emotional well-being subscale on the Short Form Health Survey-36.ResultsAfter adjustment for confounding variables, the differences for reducers compared with continuing smokers were: regression modelling -0.6 (95% CI -4.4 to 3.2) and propensity score matching 1.1 (95% CI -2.0 to 4.1).ConclusionsSmoking reduction, sustained for at least 12 weeks, was not associated with change in mental health, suggesting that reducing smoking was no better or worse for mental health than continuing smoking. Clinicians offering smoking reduction as a route to quit can be confident that, on average, smoking reduction is not associated with negative change in mental health.Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

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