• Der Anaesthesist · Mar 1995

    Review

    [Propofol: the ideal long-term sedative?].

    • A Wiebalck and H Van Aken.
    • Department of Anaesthesiology, University Hospitals, Katholieke Universiteit Leuven, Belgium.
    • Anaesthesist. 1995 Mar 1; 44 (3): 178-85.

    AbstractPropofol is commercially available as Disoprivan. It is formulated as an aqueous emulsion with 1% 2,6-diisopropylphenol, 10% soya bean oil, 2,5% glycerol and 1.2% egg phosphatide. Since 1986, propofol has been used as a sedative drug in the ICU and is highly valued for its numerous positive qualities. High effectiveness is combined with excellent control, which is demonstrably still present even after 2 weeks of sedation. This control enables short-term neurological surveillance of the patient and rapid weaning from the respirator once drug administration is stopped. Propofol does not disturb cerebral autoregulation. Depression of spontaneous breathing facilitates the ventilation of intubated patients. As the solution contains lipids, it contributes to parenteral nutrition. All in all, ease of control and rapid response make propofol a highly valued product in ICUs. It is easy to understand why many ICU specialists consider propofol an ideal drug for long-term sedation. The present authors, however, are convinced that certain limitations must be taken into account. First, cardiovascular depression, especially if potentiated by drugs such as beta- and Ca-entry blockers, may lead to hypotensive episodes. Potential problems (drug tolerance, hypertriglyceridaemia) may be revealed in long-term studies. As long as no such studies have been presented, the authors believe that it is too early to consider propofol the ideal drug for long-term sedation.

      Pubmed     Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…