• Critical care clinics · Oct 1996

    Review

    Near-infrared spectroscopy. Clinical applications.

    • S G Simonson and C A Piantadosi.
    • Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina, USA.
    • Crit Care Clin. 1996 Oct 1; 12 (4): 1019-29.

    AbstractNIRS is an attractive monitoring technology because it is a noninvasive, real-time, repeatable method that allows for regional assessment of the adequacy of tissue oxygenation. It is able to evaluate the oxygenation state of hemoglobin in tissue and redox state of cyt a1,a3, which reflects the overall activity of oxidative metabolism in the cells. The primary technical limitation of current technology is the inability to measure accurately the optical pathlength online, limiting the ability to quantify precisely concentrations of oxygen-dependent chromophores. Even with this limitation, NIRS can provide unique and valuable in vivo metabolic information without invasive intervention.

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