• Am. J. Med. Sci. · May 2008

    Case Reports

    Humoral hypercalcemia of benignancy secondary to parathyroid hormone-related protein secreting uterine leiomyoma.

    • Selcuk Dagdelen, Isilay Kalan, and Alper Gurlek.
    • Department of Endocrinology and Metabolism, Hacettepe University School of Medicine, Ankara, Turkey. dagdelen@hacettepe.edu.tr
    • Am. J. Med. Sci. 2008 May 1; 335 (5): 407-8.

    AbstractA 48-year-old women admitted with polyuria and polydipsia. She was found to be hypercalcemic despite suppressed parathormone (iPTH) levels. Subsequently checked parathormone related-protein (PTHrP) level was 2.5 pmol/L (expected normal level <1.3 pmol/L). An extensive workup for a malignancy revealed no abnormality, except for an uterine leiomyoma, 7.1 cm in size. Total abdominal hysterectomy and salpingo-oophorectomy were performed. After the surgical removal of uterine leiomyoma, serum calcium (9.3 mg/dL), iPTH (29.4 pg/mL), and PTHrP (<1.3 pmol/L) levels were normalized. The diagnosis of humoral hypercalcemia of benignancy secondary to PTHrP was confirmed. One month later, her calcium and iPTH levels were normal and 1 year later still remain within the normal ranges. Our case indicates that PTHrP associated hypercalcemia does not solely result from a malignant tumor. Benign tumors like uterine leiomyoma might also cause humoral hypercalcemia.

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