• Bmc Surg · May 2014

    Review Meta Analysis

    Perioperative blood transfusion adversely affects prognosis after resection of lung cancer: a systematic review and a meta-analysis.

    • Haixing Luan, Feng Ye, Lupeng Wu, Yanming Zhou, and Jie Jiang.
    • Department of Hepatobiliary & Pancreatovascular Surgery, Oncologic Center of Xiamen; First affiliated Hospital of Xiamen University, Xiamen 361003, China. zhouymsxy@sina.cn.
    • Bmc Surg. 2014 May 23; 14: 34.

    BackgroundIt is speculated that blood transfusion may induce adverse consequences after cancer surgery due to immunosuppression. This study was intended to assess the impact of perioperative blood transfusion on the prognosis of patients who underwent lung cancer resection.MethodsEligible studies were identified through a computerized literature search. The pooled relative risk ratio (RR) with 95% confidence interval (CI) was calculated using Review Manager 5.1 Software.ResultsEighteen studies with a total of 5915 participants were included for this meta-analysis. Pooled analysis showed that perioperative blood transfusion was associated with worse overall survival (RR: 1.25, 95% CI: 1.13-1.38; P <0.001) and recurrence-free survival (RR: 1.42, 95% CI: 1.20-1.67; P <0.001) in patients with resected lung cancer.ConclusionsPerioperative blood transfusion appears be associated with a worse prognosis in patients undergoing lung cancer resection. These data highlight the importance of minimizing blood transfusion during surgery.

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