• Antoine Kimmoun, Alain Cariou, Etienne Gayat, Elodie Feliot, Koji Takagi, Bruno Megarbane, Alexandre Mebazaa, Nicolas Deye, and FROG-ICU Study investigators.
• Medical Intensive Care Unit, Nancy University Hospital, University of Lorraine, Nancy, France; UMR-S 942, INSERM, Paris, France; U1116, INSERM, Nancy, France.
• Resuscitation. 2020 Jan 1; 146: 237-246.

ObjectiveWhile cardiac arrest (CA) patients discharged alive from intensive care unit (ICU) are considered to have good one-year survival but potential neurological impairment, comparisons with other ICU sub-populations non-admitted for CA purpose are still lacking. This study aimed to compare long-term outcome and health-related quality of life (HRQOL) between CA patients and patients admitted to ICU for all other causes.MethodsIn 1635 patients discharged alive from 21 European ICUs in an ancillary analysis of a prospective multicentric cohort, we compared CA causes of ICU admission to all other causes of ICU admissions (named non-CAs). The primary endpoint was one-year survival rate after ICU discharge. Secondary endpoints included HRQOL at 3, 6 and 12 months after ICU discharge using the outcome survey short form-36 (SF36). Propensity score matching was used to consider the probability of having CA.ResultsOf the 1635 patients, 1561 were included in this study comprised of 1447 non-CAs and 114 CAs. At one-year in the non-matched population, survival rate was greater in the CA group 89% versus the non-CA group 78% (log rank p = 0.0056). In the matched population, this difference persisted between CAs and non-CAs (log rank p = 0.049). The physical component summary of the SF36 scale was higher in the CA group than in the non-CA group at all time points in both non-matched and matched populations.ConclusionsCA patients discharged alive from ICU have a better one-year survival and a better HRQOL specifically on physical functions than patients admitted to ICU for other causes.Trial RegistrationClinicalTrials.gov NCT01367093; registered on June 6, 2011.Copyright © 2019 Elsevier B.V. All rights reserved.

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