• Jeffrey L Thomas, Joshua E Wilk, Lyndon A Riviere, Dennis McGurk, Carl A Castro, and Charles W Hoge.
• Walter Reed Army Institute of Research, Department of Military Psychiatry, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA. jeffrey.l.thomas@us.army.mil
• Arch. Gen. Psychiatry. 2010 Jun 1; 67 (6): 614-23.

ContextA growing body of literature has demonstrated the association of combat in Iraq and Afghanistan with postdeployment mental health problems, particularly posttraumatic stress disorder (PTSD) and depression. However, studies have shown varying prevalence rates of these disorders based on different case definitions and have not assessed functional impairment, alcohol misuse, or aggressive behavior as comorbid factors occurring with PTSD and depression.ObjectivesTo (1) examine the prevalence rates of depression and PTSD using several case definitions including functional impairment, (2) determine the comorbidity of alcohol misuse or aggressive behaviors with depression or PTSD, and (3) compare rates between Active Component and National Guard soldiers at the 3- and 12-month time points following their deployment to Iraq.DesignPopulation-based, cross-sectional study.SettingUnited States Army posts and National Guard armories.ParticipantsA total of 18 305 US Army soldiers from 4 Active Component and 2 National Guard infantry brigade combat teams.InterventionsBetween 2004 and 2007, anonymous mental health surveys were collected at 3 and 12 months following deployment.Main Outcome MeasuresCurrent PTSD, depression, functional impairment, alcohol misuse, and aggressive behavior.ResultsPrevalence rates for PTSD or depression with serious functional impairment ranged between 8.5% and 14.0%, with some impairment between 23.2% and 31.1%. Alcohol misuse or aggressive behavior comorbidity was present in approximately half of the cases. Rates remained stable for the Active Component soldiers but increased across all case definitions from the 3- to 12-month time point for National Guard soldiers.ConclusionsThe prevalence rates of PTSD and depression after returning from combat ranged from 9% to 31% depending on the level of functional impairment reported. The high comorbidity with alcohol misuse and aggression highlights the need for comprehensive postdeployment screening. Persistent or increased prevalence rates at 12 months compared with 3 months postdeployment illustrate the persistent effects of war zone service and provide important data to guide postdeployment care.

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