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- C D Smith, D Snowdon, and W R Markesbery.
- Sanders-Brown Center on Aging, University of Kentucky Medical Center, Lexington 40536, USA.
- J Neuroimaging. 2000 Jan 1; 10 (1): 13-6.
AbstractPeriventricular white matter hyperintensities on postmortem magnetic resonance imaging (MRI) and myelin-stained frontal and parietal histologic sections were evaluated independently in 12 cases. There was a strong relationship between the extent of white matter hyperintensities on MRI and the extent of gross and microscopic changes seen in the white matter of myelin-stained sections, particularly in the frontal lobe. In this material, the extent of myelin rarefaction correlated with a 0- to 8-point white matter hyperintensity scale rating on MRI in the same brains.
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