• J Neuroimaging · Apr 2001

    Case Reports

    HIV-2 infection with cerebral toxoplasmosis and lymphomatoid granulomatosis.

    • M Issakhanian, L Chang, M Cornford, M Witt, O Speck, M Goldberg, and T Ernst.
    • Department of Neurology, University of California, Los Angeles (UCLA) School of Medicine, Harbor-UCLA Medical Center, Torrance, CA, USA.
    • J Neuroimaging. 2001 Apr 1; 11 (2): 212-6.

    AbstractA Nigerian man had acute onset of headache and vertigo due to a cerebellar mass. A brain biopsy of the mass revealed toxoplasmosis despite repeated negative HIV-1 serology. The presence of an opportunistic infection and his country of origin raised the suspicion for HIV-2; this was confirmed by positive HIV-2 serology. Despite his preliminary pathological diagnosis, results of physiological magnetic resonance imaging (MRI) (perfusion MRI and proton magnetic resonance spectroscopy) were not typical for toxoplasmosis. The lesion showed a biochemical and perfusion pattern that was intermediate for infectious and neoplastic processes. Further neuropathology confirmed a secondary diagnosis of lymphomatoid granulomatosis.

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