• J Neuroimaging · Oct 2001

    Comparative Study

    Segmentation of progressive multifocal leukoencephalopathy lesions in fluid-attenuated inversion recovery magnetic resonance imaging.

    • L Itti, L Chang, and T Ernst.
    • Department of Computer Science, University of Southern California, Hedco Neuroscience Building, Room 30A, 3641 Watt Way, Los Angeles, CA 90089-2520, USA. itti@pollux.usc.edu
    • J Neuroimaging. 2001 Oct 1; 11 (4): 412-7.

    Background And PurposeThe authors compared the reproducibility of a manual and a semiautomated technique for the quantitation of white-matter lesions in magnetic resonance imaging (MRI).MethodsVolumes of white-matter lesions were determined using fluid-attenuated inversion recovery MRI in 23 AIDS patients with progressive multifocal leukoencephalopathy. Manual outlining was compared to an automated method based on region growing and adaptive thresholding.ResultsLesion volumes from the 2 methods correlated well (61 lesions, r = 0.99, P < 10(-4)), although the volumes differed substantially (12.8% +/- 13.7%). Interscan, intrasubject reproducibility was better for the automated than the manual method (2.9% +/- 3.2% vs 12.4% +/- 16.2% volume difference, P = .02).ConclusionThe automated algorithm appeared more reproducible, which renders it superior to the manual method for longitudinal studies.

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