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Critical care clinics · Apr 2000
ReviewImmunologic response to infection and its role in septic shock.
- L C Casey.
- Department of Medicine, Rush Medical College, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois, USA.
- Crit Care Clin. 2000 Apr 1; 16 (2): 193-213.
AbstractIn summary, the invasion of bacteria across mucosal surfaces is met with a vigorous host response that includes complement, antibody formation (thymus-independent and eventually thymus-dependent), phagocytosis, production of antibacterial peptides and proteins, the production of cytokines that result in activation of phagocytes and endothelial cells to attract more phagocytes, and the formation of fibrin to limit the spread of infection. The best summary of immune response to infection was written by Lewis Thomas in 1974.
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