• Critical care clinics · Jan 2001

    Review

    Lipid modulation and systemic inflammation.

    • G P Zaloga and P Marik.
    • Suburban Hospital, Bethesda, Maryland, USA.
    • Crit Care Clin. 2001 Jan 1; 17 (1): 201-17.

    AbstractN-6 and n-3 PUFAs from the diet are absorbed and reach the cell where they interact with fatty acid binding proteins within cell membranes and cytoplasm. They are processed in the endoplasmic reticulum (desaturation-elongation reactions, lipid synthesis, eicosanoid and epoxide production) and in peroxisomes (beta-oxidation, synthesis, oxidation products). They interact with receptors, ion channels, and nuclear elements; the result is modulation of gene expression. PUFA-induced alterations result in modulation of local and systemic inflammation and inflammatory disease activity.

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