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- Esther Kors, Joost Haan, and Michel Ferrari.
- Department of Neurology, K5Q, Leiden University Medical Centre, PO Box 9600, 2300 RC Leiden, The Netherlands.
- Curr Pain Headache Rep. 2003 Jun 1; 7 (3): 212-7.
AbstractThe genetics of migraine is a fascinating and moving research area. Familial hemiplegic migraine, a rare subtype of migraine with a Mendelian pattern of inheritance, is caused by mutations in the chromosome 19 CACNA1A gene in approximately 75% of the families. The finding of mutations in an ionchannel subunit defines migraine as a channelopathy (eg, epilepsy). The genetics of the more frequent variants, migraine with and without aura, is more complex. Several loci have been studied in families and case-control studies, but need to be confirmed.
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