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Curr Pain Headache Rep · Dec 2003
ReviewCentral and peripheral sensitization in tension-type headache.
- Lars Bendtsen.
- Danish Headache Center, University of Copenhagen, and Department of Neurology, Glostrup University Hospital, DK-2600 Glostrup, Copenhagen, Denmark. bendtsen@dadlnet.dk
- Curr Pain Headache Rep. 2003 Dec 1; 7 (6): 460-5.
AbstractRecent studies on tension-type headache indicate that the nociceptive input to the central nervous system may be increased as a result of activation or sensitization of peripheral sensory afferents. Moreover, pain perception studies and pharmacologic studies strongly suggest that the central nervous system is sensitized in patients with chronic tension-type headache. The barrage of nociceptive impulses from the periphery may be responsible for the sensitization of second- and third-order neurons in the central nervous system. In this way, sensitization may play a role in the initiation and maintenance of tension-type headache. Studies have demonstrated that treatment with drugs that counteract sensitization has an analgesic effect on tension-type headache. Targeting this mode of action seems to be a promising way of improving the treatment for this prevalent disorder.
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