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Curr Pain Headache Rep · Jun 2004
ReviewToward a molecular genetic classification of familial hemiplegic migraine.
- Joost Haan, Esther E Kors, Arn M J M van den Maagdenberg, Kaate R J Vanmolkot, Gisela M Terwindt, Rune R Frants, and Michel D Ferrari.
- Department of Neurology (K5Q), Leiden University Medical Centre, PO Box 9600, 2300 RC Leiden, The Netherlands.
- Curr Pain Headache Rep. 2004 Jun 1; 8 (3): 238-43.
AbstractThe genetics of migraine is a fascinating and rapidly moving research area. Familial hemiplegic migraine, a rare subtype of migraine with a Mendelian pattern of inheritance, is caused by mutations in the chromosome 19 CACNA1A gene or in the chromosome 1 ATP1A2 gene. Familial migraine variants are classified on the basis of clinical, descriptive criteria, but this is insufficient. In the future, a diagnostic classification based on mutation-analysis is needed.
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