• Biochem. Biophys. Res. Commun. · Jan 2000

    Coordinate recruitment of E-cadherin and ALCAM to cell-cell contacts by alpha-catenin.

    • K Tomita, A van Bokhoven, C F Jansen, M J Bussemakers, and J A Schalken.
    • Urology Research Laboratory, University Hospital Nijmegen, Nijmegen, 6500 HB, The Netherlands.
    • Biochem. Biophys. Res. Commun. 2000 Jan 27; 267 (3): 870-4.

    AbstractHere we report on the role of alpha-catenin in the cellular localization of activated leukocyte cell adhesion molecule, ALCAM, and cadherin-mediated cell adhesion in human prostate cancer cells. Cell lines that have a functional E-cadherin-mediated cell adhesion (DU-145 and LNCaP) show ALCAM staining at cell-cell contacts. In contrast, in cell lines that lack alpha-catenin expression (ALVA-31, PC-3, and PPC-1), E-cadherin-mediated adhesion is disturbed and ALCAM staining is cytoplasmic. A role of alpha-catenin in the recruitment of E-cadherin and ALCAM to cell-cell contacts was established by transfection of an alpha-N-catenin construct into cell lines ALVA-31 and PC-3. This resulted not only in the correct assembly of E-cadherin/alpha-catenin complexes at the cell membrane but also in localization of ALCAM to cell-cell contacts, indicating that indeed alpha-catenin affects ALCAM localization.Copyright 2000 Academic Press.

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