• Emmanuel Andrès, Noureddine Henoun Loukili, Esther Noel, Georges Kaltenbach, Maher Ben Abdelgheni, Anne Elisabeth Perrin, Marie Noblet-Dick, Frédéric Maloisel, Jean-Louis Schlienger, and Jean-Frédéric Blicklé.
• Department of Internal Medicine, Medical Clinic B, Strasbourg University Hospitals, Strasbourg, France. emmanuel.andres@chru-strasbourg.fr
• CMAJ. 2004 Aug 3; 171 (3): 251259251-9.

AbstractVitamin B12 or cobalamin deficiency occurs frequently (> 20%) among elderly people, but it is often unrecognized because the clinical manifestations are subtle; they are also potentially serious, particularly from a neuropsychiatric and hematological perspective. Causes of the deficiency include, most frequently, food-cobalamin malabsorption syndrome (> 60% of all cases), pernicious anemia (15%-20% of all cases), insufficient dietary intake and malabsorption. Food-cobalamin malabsorption, which has only recently been identified as a significant cause of cobalamin deficiency among elderly people, is characterized by the inability to release cobalamin from food or a deficiency of intestinal cobalamin transport proteins or both. We review the epidemiology and causes of cobalamin deficiency in elderly people, with an emphasis on food-cobalamin malabsorption syndrome. We also review diagnostic and management strategies for cobalamin deficiency.

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