• Crit Care · Apr 2002

    Review

    Toll-like receptors: the key to the stable door?

    • Philip Hopkins and Jonathan Cohen.
    • Clinical Research Fellow, Department of Infectious Diseases, Hammersmith Hospital, London, UK. p.hopkins@ic.ac.uk
    • Crit Care. 2002 Apr 1; 6 (2): 99-101.

    AbstractSevere sepsis continues to lead to critical illness. Few therapeutic options exist other than antibiotic therapy and general supportive care. Large numbers of patients continue to die as a consequence of overactivation of the host inflammatory response and the resultant coagulopathy and disregulation of the normal controls of vasoactive tone. It is now known that a critical part of this host response occurs at the level of innate defence, without the need for antigen processing or the clonal expansion of cells targeted against the invading pathogen. This commentary will discuss the therapeutic targets revealed by our new understanding of the Toll-like receptor. The potential clinical difficulties that may result from intervention at this pattern-recognition receptor will also be explored.

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