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Int J Obstet Anesth · Apr 1996
The role of serotonin in preeclamptic hypertension. A review and case report.
- C Hutter, I M Crighton, K Smith, and D T Liu.
- Department of Anaesthetics & Obstetrics, City Hospital, Nottingham, UK.
- Int J Obstet Anesth. 1996 Apr 1; 5 (2): 108-14.
AbstractGeneralized arteriolar vasospasm and subsequent damage to vascular endothelium are fundamental to the development of preeclampsia. A possible mechanism underlying this involves increased deportation of trophoblast cells into maternal venous circulation with 5-hydroxytryptamine (serotonin, 5-HT) release as a consequence of platelet aggregation onto these fragments. Ketanserin, a 5-HT(2) receptor blocker, has been used successfully to treat preeclampsia. An examination of the therapeutic role of ketanserin indicates that there should now be a much more detailed assessment of serotonin antagonists in the treatment and prophylaxis of preeclampsia and eclampsia.
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