• Yoshiyuki Takahashi, Shigeki Yamaguchi, Masatomo Tezuka, Yoshiyuki Kimura, Masaru Nagao, Hajime Yamazaki, and Shinsuke Hamaguchi.
• Department of Anesthesiology, Dokkyo University School of Medicine, Tochigi, Japan.
• Reg Anesth Pain Med. 2004 Sep 1; 29 (5): 441-5.

Background And ObjectivesThe aim of this study is to compare 0.2% ropivacaine with 0.125% bupivacaine or 0.25% bupivacaine for the duration and magnitude of the vasodilation effect induced by sympathetic block.MethodsWe measured mean arterial pressure, heart rate, and right and left brachial artery blood flow (BABF) before and after cervicothoracic sympathetic block in 24 dogs. The experimental protocol was designed as follows: (1) left cervicothoracic sympathetic block with 1.0 mL 0.2% ropivacaine (n =8), (2) left cervicothoracic sympathetic block with 1.0 mL 0.125% bupivacaine (n=8), and (3) left cervicothoracic sympathetic block with 1.0 mL 0.25% bupivacaine (n=8).ResultsMean arterial pressure and heart rate did not change significantly throughout the study in either group. Left cervicothoracic sympathetic block with 0.2% ropivacaine increased left BABF significantly from 5 to 100 minutes after the block (baseline, 100%; peak at 10 minutes after the block, 254 +/- 38%; P <.01). Left cervicothoracic sympathetic block with 0.125% bupivacaine increased left BABF significantly from 5 to 80 minutes after the block (baseline, 100%; peak at 10 minutes after the block, 144 +/- 9%; P <.01). Left cervicothoracic sympathetic block with 0.25% bupivacaine increased left BABF significantly from 5 to 100 minutes after the block (baseline, 100%; peak at 10 minutes after the block, 235 +/- 61%; P <.01).ConclusionRopivacaine may be equally potent to bupivacaine at equal concentrations in sympathetic block in dogs.

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