• Y Kuroda, M Murakami, J Tsuruta, T Murakawa, and Y Shiroyama.
• Department of Anesthesia, Yamaguchi Riosai Hospital, Onoda, Japan.
• J Anesth. 2000 Jan 1; 14 (3): 128-4.

PurposeTo examine the changes in cerebral blood flow (CBF) equivalent (CBF divided by cerebral metabolic rate for oxygen) during craniotomy under isoflurane and sevoflurane anesthesia in patients with intracranial disorders.MethodsIn 16 neurosurgical patients (8 anesthetized with isoflurane and 8 with sevolflurane), the CBF equivalent was measured while the end-tidal concentration of the selected volatile anesthetic was maintained at 0.5 and 1.0 minimum alveolar concentration (MAC) before surgery, and then 1.0 MAC during surgery, which lasted more than 4 hr.ResultsThere was no significant difference in CBF equivalent at 0.5 MAC between isoflurane (20 +/- 4ml blood.ml oxygen) groups. With increasing anesthetic depth from 0.5 to 1.0 MAC, the CBF equivalent significantly (P<0.5) increased in both groups (22 +/- 7 and 21 +/- 5, respectively). At 1.0 MAC during operation, the CBF equivalent with both anesthetics was maintained with minimal fluctuation for 4h. There were no significant differences in the average value of the CBF equivalent during a 4-h period at 1.0 MAC between the isoflurane (23 +/- 5) and the sevoflurane (20 +/- 4) groups.ConclusionDeepening anesthesia from 0.5 to 1.0 MAC was maintained with no difference between the two agents during 4h of neurosurgery.

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